Symbol
Name
ID

Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
MGI:97583

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes

Decreased circulating IgA level

Decreased circulating IgG level

Increased circulating IgM level

Agammaglobulinemia

Panhypogammaglobulinemia

Neutropenia

Increased proportion of transitional B cells

B lymphocytopenia

Decreased proportion of naive CD4 T cells

Decreased proportion of naive CD8 T cells

Lymphopenia

Reduced natural killer cell count

Abnormal T cell morphology

Chronic lymphatic leukemia

B-cell lymphoma

Splenomegaly

Disease(s) Associated with PIK3R1

agammaglobulinemia 7

immunodeficiency 36

Mouse Phenotypes

decreased B cell proliferation

abnormal erythropoiesis

abnormal B cell differentiation

decreased immature B cell number

decreased pro-B cell number

increased pro-B cell number

arrested B cell differentiation

decreased mature B cell number

decreased B-1 B cell number

decreased B-1a cell number

decreased B-1b cell number

decreased B-2 B cell number

increased B-1b cell number

decreased B cell number

decreased pre-B cell number

increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number

increased CD8-positive, alpha-beta memory T cell number

decreased NK T cell number

abnormal B cell physiology

Availability

Mouse Genotype

Pik3r1^m1Btlr/Pik3r1^m1Btlr

Pik3r1^m3Btlr/Pik3r1^m3Btlr

Pik3r1^tm1Dfr/Pik3r1^tm1Dfr

Pik3r1^tm1Tka/Pik3r1^tm1Tka

Pik3r1^tm2Dfr/Pik3r1^tm2Dfr

Pik3r1^M2Btlr/Pik3r1⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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